![]() ![]() ![]() This notion has been revisited in recent years and numerous studies concerning the axonal regulation of myelination have attempted to address this particular assumption. Myelination of axons is dictated, in large part, by axonal signals that control the development of myelinating glia, and it has long been thought that axon diameter is the key determining factor for the initiation of myelination. Although some axons are myelinated and others remain unmyelinated, what are the factors that determine the expression of these signals along axons, what are these signals, and how are these signals regulated throughout development? Although the axonal factors that induce differentiation and myelination are still in question, it is well accepted that axons also control whether they will become myelinated by expressing appropriate signals to either promote or inhibit this process ( Colello and Pott, 1997). It is generally believed that during development axons will control the proliferation, survival, and differentiation of the oligodendrocyte progenitor cell (OPC). The formation of the myelin sheath is an exquisite and dynamic example of cell–cell interaction that involves the myelin-forming cell and the neuronal axon. The implications of these results relate specifically to the development of potential therapeutics targeting extrinsic growth factors that may regulate the axonal expression of modulators of oligodendrocyte development. Myelination was greatly inhibited in the presence of enforced axonal LINGO-1. Furthermore, these results were recapitulated in transgenic mice overexpressing the full length LINGO-1 under the neuronal promoter synapsin. Disruption of LINGO-1 on either cell type is sufficient to overcome the inhibitory action and promote differentiation and myelination, independent of axon diameter. Whereas LINGO-1 expressed by oligodendrocyte progenitor cells was previously identified as an inhibitor of differentiation, we demonstrate that axonal expression of LINGO-1 inhibits differentiation with equal potency. Here, we identify LRR and Ig domain-containing, Nogo receptor-interacting protein (LINGO-1) as a potent axonal inhibitor of oligodendrocyte differentiation and myelination that is regulated by nerve growth factor and its cognate receptor TrkA in a dose-dependent manner. Slang adds flavor to your spoken English.Neurons and glia share a mutual dependence in establishing a functional relationship, and none is more evident than the process by which axons control myelination. Eavesdrop on some conversations, and practice on your “acere”. The other, more particular, Florida slang takes a minute to get the hang of-especially the Cuban influenced slang because the pronunciation is specific. The students of all the South Florida TALK School locations agree that “have a good one”, and “hola” are the slang you’ll hear most often. ![]() “The Florijority” Florida has decided many contentious elections, and landed on the not reeeally open-minded end of things-“The Florijority showed up and pulled the lever!” “Floridabulous” super cliché, trashy, weird, and without reason “Florida Happy Meal” a pack of ‘smokes’ (cigarettes), a 12 pack of beer, and lottery tickets “Florida bath” basically you’re getting clean in a pool, not the shower! “Buss/ bussin” good food, great food, DELICIOUS food!! “Sleep” to be missing out on something-“You are ‘sleepin’ – that club is hot!” “Bap” an obsolete or broken thing, usually something tech “Slide” to invite over/to come over/to go over to-“slide” on by my haaz after class.” (Haaz=houseJ) “Vibin/vibing” is “chillin” everywhere else-so kickin’ back and relaxing ![]() “Jit” usually a kid, but it can be anyone younger than you-“Jit” made a move on my sister!” “Bih” a person, place, or thing: “what’s up with that bih?” “Dale” you can thank the singer Pitbull for this-apparently, he says it A LOT! It usually means “bye”, but can also mean “come on” or “hurry up”. “Acere” this means “pal”, “buddy”, “friend” “Oye” that’s “hey” as in “hello” it’s a super shorthand for the Cuban phrase: “?oye que bola?” or “hey, what’s up?” “Hola” “Hola Mama” “ Bienvenita ” all 3 are “hello”, the addition of “mama” is a bit of a leering “hello” to a girl/woman “Have a good one” a friendly way to say “goodbye–have a nice day” Sure, South Florida slang can vary by city and even neighborhood, but the listeners in Fort Lauderdale know their South Beach speak too! South Florida Slang Words and Phrases The students of all 4 South Florida TALK School locations have voted on the slang you’re most likely to hear in the state. South Florida slang comes in a few varieties-Hip-Hop lingo, Cuban influenced, and those who are outside looking into this quirky state. ![]()
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